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The role of genes in disease: beware of simplistic interpretations!

Prescrire international - 1 Dec 2009

Abstract excerpt

(1) Most diseases with a strong genetic component and a Mendelian pattern of inheritance are rare or very rare disorders; (2) The most common human diseases result from complex interactions between genetic and environmental factors. They are multifactorial; (3) The simple presence of genes that are associated with a disease is not generally sufficient to determine with certainty that the signs and symptoms that...

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PMID: 20027720

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