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Transcription factor AP2‐Sp and its target genes in malarial sporozoites

16 Dec 2009

Abstract excerpt

The malarial sporozoite is the stage that infects the liver, and genes expressed in this stage are potential targets for vaccine development. Here, we demonstrate that specific gene expression in this stage is regulated by an AP2-related transcription factor, designated AP2-Sp (APETALA2 in sporozoites), that is expressed from the late oocyst to the salivary gland sporozoite. Disruption of the AP2-Sp gene did not...

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PMID: 20025671
DOI: 10.1111/j.1365-2958.2009.07005.x

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