Article
Epithelial NF-kappaB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation.
The American journal of pathology - 1 Jan 2010
Tang Yueming, Clayburgh Daniel R, Mittal Navdha, Goretsky Tatiana, Dirisina Ramanarao, Zhang Zheng, Kron Michelle, Ivancic David, Katzman Rebecca B, Grimm Gery, Lee Goo, Fryer Jonathan, Nusrat Asma, Turner Jerrold R, Barrett Terrence A
Abstract excerpt
In inflammatory bowel disease (IBD), aberrant activation of innate and adaptive immune responses enhances mucosal permeability through mechanisms not completely understood. To examine the role of epithelial nuclear factor (NF-kappaB) in IBD-induced enhanced permeability, epithelial-specific Ikapp...
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