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Article

The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small cell lung cancer cells

1 Dec 2009

Abstract excerpt

BACKGROUND: Gene targeted therapy refers to any therapy focused on one of the many biological features of the tumor. Such features are mediated by specific genes that are involved in tumor metastasis, recurrence, poor response to chemotherapy and others. Hypoxia is an important pathognomonic feature of many malignant tumors including SCLC (small cell lung cancer). HIF-1alpha, which is induced by hypoxia, is the...

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PMID: 20003295
DOI: 10.1186/1756-9966-28-150

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