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Decreased expression of neurofibromin contributes to epithelial–mesenchymal transition in neurofibromatosis type 1

30 Nov 2009

Abstract excerpt

Plexiform and/or dermal neurofibromas are nerve sheath tumors of the peripheral nervous system that are usually present in individuals with neurofibromatosis type 1 (NF1). Neurofibromas arise from Schwann cells with biallelic inactivation of NF1, the gene that encodes neurofibromin. This protein is responsible for regulation of the Ras-mediated pathway, which has been shown to play a crucial role in...

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PMID: 20002172
DOI: 10.1111/j.1600-0625.2009.01017.x

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