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Article

Conformational stability and activity of circular Enterocin AS-48 derivatives.

Protein and peptide letters - 1 Jun 2010

Sánchez-Hidalgo Marina, Fernández-Escamilla Ana M, Martínez-Bueno Manuel, Valdivia Eva, Serrano Luis, Maqueda Mercedes

Abstract excerpt

Four AS-48 mutants (Trp24Ala, Gly13Lys, Leu40Lys and Ala53Ser) were obtained by site-directed mutagenesis. The minimal inhibitory concentration of each peptide showed that only residue Trp24 was unquestionably involved in the biological activity. Guanidine hydrochloride-induced unfolding assays s...

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Identifiers

PMID: 19958277
DOI: 10.2174/092986610791190390

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19958277-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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