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Article

An oral sorbent, AST-120, increases Klotho expression and inhibits cell senescence in the kidney of uremic rats.

American journal of nephrology - 1 Jan 2010

Adijiang Ayinuer, Niwa Toshimitsu

Abstract excerpt

BACKGROUND/AIM: Klotho, an anti-aging gene, is primarily expressed in the kidney, and its renal expression is decreased in chronic renal failure (CRF). We determined if administration of an oral sorbent, AST-120, increases the expression of Klotho, and inhibits cell senescence in the kidney of CR...

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Identifiers

PMID: 19955715
DOI: 10.1159/000264634

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19955715-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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