Article
1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a selective tyrosine kinase inhibitor of fibroblast growth factor receptor-3 (FGFR3), inhibits cell proliferation of bladder cancer carrying the FGFR3 gene mutation along with up-regulation of p27/Kip1 and G1/G0 arrest.
The Journal of pharmacology and experimental therapeutics - 1 Mar 2010
Miyake Makito, Ishii Masazumi, Koyama Naoki, Kawashima Kiyotaka, Kodama Tetsuro, Anai Satoshi, Fujimoto Kiyohide, Hirao Yoshihiko, Sugano Kokichi
Abstract excerpt
Activating mutation of the fibroblast growth factor receptor-3 (FGFR3) gene is known as a key molecular event in both oncogenesis and cell proliferation of low-grade noninvasive human bladder urothelial carcinoma (UC), which is characterized by frequent intravesical recurrence. In this study, we...
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