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Article

Allelic diversity and phylogeny of homB, a novel co-virulence marker of Helicobacter pylori.

BMC microbiology - 2 Dec 2009

Oleastro Mónica, Cordeiro Rita, Ménard Armelle, Yamaoka Yoshio, Queiroz Dulciene, Mégraud Francis, Monteiro Lurdes

Abstract excerpt

BACKGROUND: The homB gene is a Helicobacter pylori disease-marker candidate, strongly associated with peptic ulcer disease, while homA, its paralogue gene with 90% sequence identity, is correlated with non-ulcer dyspepsia. The HomB encoded outer membrane protein was shown to contribute to the proinflammatory properties of H. pylori and also to be involved in bacterial adherence.This study investigated the...

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Source

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Identifiers

PMID: 19954539
DOI: 10.1186/1471-2180-9-248
PMCID: PMC2795765

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