Article
Early emergence of raltegravir resistance mutations in patients receiving HAART salvage regimens.
Journal of medical virology - 1 Jan 2010
Baldanti Fausto, Paolucci Stefania, Gulminetti Roberto, Brandolini Micaela, Barbarini Giorgio, Maserati Renato
Abstract excerpt
The emergence of drug-resistance mutations in HIV-1 integrase of patients receiving HAART salvage regimens including raltegravir was investigated in 11 heavily pretreated patients (median number of treatment failures 12, range 5-22) within an expanded access program in Pavia, Italy. HIV-1 RNA levels in plasma, CD4(+) T-cell counts and sequencing of HIV-1 reverse transcriptase (RT), protease (PR), gp41, and...
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