Article
Genomic dissection of population substructure of Han Chinese and its implication in association studies.
American journal of human genetics - 1 Dec 2009
Xu Shuhua, Yin Xianyong, Li Shilin, Jin Wenfei, Lou Haiyi, Yang Ling, Gong Xiaohong, Wang Hongyan, Shen Yiping, Pan Xuedong, He Yungang, Yang Yajun, Wang Yi, Fu Wenqing, An Yu, Wang Jiucun, Tan Jingze, Qian Ji, Chen Xiaoli, Zhang Xin, Sun Yangfei, Zhang Xuejun, Wu Bailin, Jin Li
Abstract excerpt
To date, most genome-wide association studies (GWAS) and studies of fine-scale population structure have been conducted primarily on Europeans. Han Chinese, the largest ethnic group in the world, composing 20% of the entire global human population, is largely underrepresented in such studies. A well-recognized challenge is the fact that population structure can cause spurious associations in GWAS. In this study,...
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