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Article

Human sperm chromatin stabilization: a proposed model including zinc bridges

20 Nov 2009

Abstract excerpt

The primary focus of this review is to challenge the current concepts on sperm chromatin stability. The observations (i) that zinc depletion at ejaculation allows a rapid and total sperm chromatin decondensation without the addition of exogenous disulfide cleaving agents and (ii) that the human sperm chromatin contains one zinc for every protamine for every turn of the DNA helix suggest an alternative model for...

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PMID: 19933313
DOI: 10.1093/molehr/gap099

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