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Article

Familial transposition of the great arteries caused by multiple mutations in laterality genes.

Heart (British Cardiac Society) - 1 May 2010

De Luca Alessandro, Sarkozy Anna, Consoli Federica, Ferese Rosangela, Guida Valentina, Dentici Maria Lisa, Mingarelli Rita, Bellacchio Emanuele, Tuo Giulia, Limongelli Giuseppe, Digilio Maria Cristina, Marino Bruno, Dallapiccola Bruno

Abstract excerpt

BACKGROUND: The pathogenesis of transposition of the great arteries (TGA) is still largely unknown. In general, TGA is not associated with the more common genetic disorders nor with extracardiac anomalies, whereas it can be found in individuals with lateralisation defects, heterotaxy and asplenia...

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Source

Identifiers

PMID: 19933292
DOI: 10.1136/hrt.2009.181685

Genes

ZIC3
FOXH1
NODAL
CFC1
CRELD1
GATA4
GDF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19933292-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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