Combined inhibition of IGFR enhances the effects of gefitinib in H1650: a lung cancer cell line with EGFR mutation and primary resistance to EGFR-TK inhibitors.

doi:10.1007/s00280-009-1174-7

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Article

Combined inhibition of IGFR enhances the effects of gefitinib in H1650: a lung cancer cell line with EGFR mutation and primary resistance to EGFR-TK inhibitors.

Cancer chemotherapy and pharmacology - 1 Jul 2010

Choi Yun Jung, Rho Jin Kyung, Jeon Byung-suk, Choi Su Jin, Park Su Cheol, Lee Seung Sook, Kim Hye-Ryoun, Kim Cheol Hyeon, Lee Jae Cheol

Abstract excerpt

PURPOSE: H1650 non-small cell lung cancer (NSCLC) cells display primary resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) although they have a deletion mutation on exon 19 of the EGFR gene. We investigated the effect of inhibition of both insulin-like growth fa...

Topics

Antineoplastic Agents
Apoptosis
Blotting, Western
Cell Line, Tumor
Cell Proliferation
Drug Resistance, Neoplasm
ErbB Receptors
Exons
Gefitinib
Gene Deletion
Genes, erbB-1
Humans
In Situ Hybridization, Fluorescence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Indicators and Reagents

Insulin-Like Growth Factor Binding Proteins

Lung Neoplasms

Mutation

Protein Kinase Inhibitors

Source

Open in PubMed

Identifiers

PMID: 19921194
DOI: 10.1007/s00280-009-1174-7

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-19921194-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.