Article
No severe bottleneck during human evolution: evidence from two apolipoprotein C-II deficiency alleles.
American journal of human genetics - 1 Feb 1991
Xiong W J, Li W H, Posner I, Yamamura T, Yamamoto A, Gotto A M, Chan L
Abstract excerpt
The DNA sequences of a Japanese and a Venezuelan apolipoprotein (apo) C-II deficiency allele, of a normal Japanese apo C-II gene, and of a chimpanzee apo C-II gene were amplified by PCR, and their nucleotide sequences were determined on multiple clones of the PCR products. The normal Japanese sequence is identical to--and the chimpanzee sequence differs by only three nucleotides from--a previously published...
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