No severe bottleneck during human evolution: evidence from two apolipoprotein C-II deficiency alleles.

Abstract excerpt

The DNA sequences of a Japanese and a Venezuelan apolipoprotein (apo) C-II deficiency allele, of a normal Japanese apo C-II gene, and of a chimpanzee apo C-II gene were amplified by PCR, and their nucleotide sequences were determined on multiple clones of the PCR products. The normal Japanese sequence is identical to--and the chimpanzee sequence differs by only three nucleotides from--a previously published...

Topics

• Alleles
• Animals
• Apolipoprotein C-II
• Apolipoproteins C
• Base Sequence
• Biological Evolution
• Humans
• Molecular Sequence Data
• Mutation
• Pan troglodytes
• Polymerase Chain Reaction