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Article

Vibrio cholerae cytolysin causes an inflammatory response in human intestinal epithelial cells that is modulated by the PrtV protease.

PloS one - 12 Nov 2009

Ou Gangwei, Rompikuntal Pramod Kumar, Bitar Aziz, Lindmark Barbro, Vaitkevicius Karolis, Wai Sun Nyunt, Hammarström Marie-Louise

Abstract excerpt

BACKGROUND: Vibrio cholerae is the causal intestinal pathogen of the diarrheal disease cholera. It secretes the protease PrtV, which protects the bacterium from invertebrate predators but reduces the ability of Vibrio-secreted factor(s) to induce interleukin-8 (IL-8) production by human intestinal epithelial cells. The aim was to identify the secreted component(s) of V. cholerae that induces an epithelial...

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PMID: 19907657
DOI: 10.1371/journal.pone.0007806
PMCID: PMC2771358

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