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Article

Advances in the pathophysiology of tension-type headache: from stress to central sensitization.

Current pain and headache reports - 1 Dec 2009

Chen Yaniv

Abstract excerpt

Tension-type headache (TTH) is the most common and most socioeconomically costly headache. Yet our knowledge regarding TTH pathophysiological mechanisms is still in its early stages. Psychological stress and weak coping mechanisms may initiate and propagate physiological pain via activation of second messengers in downstream substrates involved in pain. It seems that peripheral mechanisms are predominant in the...

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PMID: 19889292
DOI: 10.1007/s11916-009-0078-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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