Article
Bioinformatics approaches for genomics and post genomics applications of next-generation sequencing.
Briefings in bioinformatics - 1 Mar 2010
Horner David Stephen, Pavesi Giulio, Castrignanò Tiziana, De Meo Paolo D'Onorio, Liuni Sabino, Sammeth Michael, Picardi Ernesto, Pesole Graziano
Abstract excerpt
Technical advances such as the development of molecular cloning, Sanger sequencing, PCR and oligonucleotide microarrays are key to our current capacity to sequence, annotate and study complete organismal genomes. Recent years have seen the development of a variety of so-called 'next-generation' sequencing platforms, with several others anticipated to become available shortly. The previously unimaginable scale and...
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