Article
Mismatch correction modulates mutation frequency and pilus phase and antigenic variation in Neisseria gonorrhoeae.
Journal of bacteriology - 1 Jan 2010
Criss Alison K, Bonney Kevin M, Chang Rhoda A, Duffin Paul M, LeCuyer Brian E, Seifert H Steven
Abstract excerpt
The mismatch correction (MMC) system repairs DNA mismatches and single nucleotide insertions or deletions postreplication. To test the functions of MMC in the obligate human pathogen Neisseria gonorrhoeae, homologues of the core MMC genes mutS and mutL were inactivated in strain FA1090. No mutH homologue was found in the FA1090 genome, suggesting that gonococcal MMC is not methyl directed. MMC mutants were...
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