Article
A favorable metabolic and antiatherogenic profile in carriers of CYP21A2 gene mutations supports the theory of a survival advantage in this population.
Hormone research - 1 Jan 2009
Livadas Sarantis, Dracopoulou Maria, Lazaropoulou Christina, Papassotiriou Ioannis, Sertedaki Amalia, Angelopoulos G Nick, Chrousos George P, Dacou-Voutetakis Catherine
Abstract excerpt
CONTEXT: The very high carrier frequency of 21-hydroxylase deficiency worldwide has been postulated as indicating a survival advantage. The 'mediators' of such an effect remain speculative. OBJECTIVE: To look for possible differences in the metabolic and atherogenic risk profile of carriers and noncarriers of CYP21A2 gene mutations at puberty in order to identify possible mediators of the presumed survival...
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