Article
The theory of discovering rare variants via DNA sequencing.
BMC genomics - 20 Oct 2009
Wendl Michael C, Wilson Richard K
Abstract excerpt
BACKGROUND: Rare population variants are known to have important biomedical implications, but their systematic discovery has only recently been enabled by advances in DNA sequencing. The design process of a discovery project remains formidable, being limited to ad hoc mixtures of extensive computer simulation and pilot sequencing. Here, the task is examined from a general mathematical perspective. RESULTS: We...
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