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Modification of survival pathway gene expression in human breast cancer cells by tetraiodothyroacetic acid (tetrac)

1 Nov 2009

Abstract excerpt

Tetraiodothyroacetic acid (tetrac) inhibits the cellular actions of thyroid hormone initiated at the hormone receptor on plasma membrane integrin alphavbeta3. Via interaction with the integrin, tetrac is also capable of inhibiting the angiogenic effects of vascular endothelial growth factor and basic fibroblast growth factor. MDA-MB-231 cells are estrogen receptor-negative human breast cancer cells shown to be...

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PMID: 19838061
DOI: 10.4161/cc.8.21.9963

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