Article
Pericentric inversion of chromosome 9: prevalence in 300 Down syndrome families and molecular studies of nondisjunction.
American journal of medical genetics. Supplement - 1 Jan 1990
Serra A, Brahe C, Millington-Ward A, Neri G, Tedeschi B, Tassone F, Bova R
Abstract excerpt
The incidence of Down syndrome (DS) families where one of the parents is an heterozygous carrier of pericentric inversion of the heterochromatic region of chromosome 9-inv(9) (qh) - was determined in 3 independent groups of 100 families each. The total number of 17 such families found in the samp...
Topics
- Chromosome Inversion
- Chromosomes, Human, Pair 9
- Down Syndrome
- Female
- Genotype
- Heterozygote
- Homozygote
- Humans
- Infant, Newborn
- Male
- Nondisjunction, Genetic
- Polymorphism, Restriction Fragment Length