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Article

TLR4 and IL-18 gene variants in chronic periodontitis: impact on disease susceptibility and severity.

Immunological investigations - 1 Jan 2009

Noack Barbara, Görgens Heike, Lorenz Katrin, Schackert Hans Konrad, Hoffmann Thomas

Abstract excerpt

The aim of the study was to assess whether genotypes in the Toll-like receptor 4 gene and in the promoter of the interleukin-18 gene are associated with the susceptibility to chronic periodontitis. 108 chronic periodontitis patients and 76 controls were genotyped for c.896A>G/1196C>T (TLR4 gene) and for c.-368G>C/ c.-838C>A (IL-18 promoter). There were no significant differences in genotype and allele...

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Source

Identifiers

PMID: 19811440
DOI: 10.1080/08820130902846290

Genes

TLR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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