The IL1A (-889) gene polymorphism is associated with chronic periodontal disease in a sample of Brazilian individuals.

doi:10.1111/j.1600-0765.2006.00910.x

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Article

The IL1A (-889) gene polymorphism is associated with chronic periodontal disease in a sample of Brazilian individuals.

Journal of periodontal research - 1 Feb 2007

Moreira P R, Costa J E, Gomez R S, Gollob K J, Dutra W O

Abstract excerpt

BACKGROUND AND OBJECTIVE: It has been proposed that genotypes reflective of polymorphisms in cytokine genes can predispose individuals to disease by enhancing inflammatory processes. The C/T polymorphism at position -889 of the IL1A gene influences interleukin-1alpha expression, with the T allele inducing higher expression. The aim of this study was to evaluate the association of the IL1A (-889) gene polymorphism...

Topics

Adolescent
Adult
Aged
Alleles
Brazil
Chronic Disease
Cross-Sectional Studies
Cytosine
DNA
Female
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-1alpha

Male

Middle Aged

Periodontitis

Polymorphism, Genetic

Smoking

Source

Open in PubMed

Identifiers

PMID: 17214636
DOI: 10.1111/j.1600-0765.2006.00910.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17214636-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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