Article
Matrix metalloproteinases and their tissue inhibitors in cardiac amyloidosis: relationship to structural, functional myocardial changes and to light chain amyloid deposition.
Circulation. Heart failure - 1 Nov 2008
Biolo Andreia, Ramamurthy Sujata, Connors Lawreen H, O'Hara Carl J, Meier-Ewert Hans K, Soo Hoo Pamela T, Sawyer Douglas B, Seldin David C, Seldin David S, Sam Flora
Abstract excerpt
BACKGROUND: Cardiac amyloidosis is characterized by amyloid infiltration resulting in extracellular matrix disruption. Amyloid cardiomyopathy due to immunoglobulin light chain protein (AL-CMP) deposition has an accelerated clinical course and a worse prognosis compared with non-light chain cardia...
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