Prevalence and Prognostic Significance of Restriction Versus Systolic Dysfunction in Patients With Transthyretin and Light Chain Cardiac Amyloidosis.

doi:10.1161/CIRCHEARTFAILURE.125.012337

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Prevalence and Prognostic Significance of Restriction Versus Systolic Dysfunction in Patients With Transthyretin and Light Chain Cardiac Amyloidosis.

Circulation. Heart failure - 1 Mar 2026

Zampieri Mattia, Biagioni Giulia, Del Franco Annamaria, Canepa Marco, Porto Italo, Zanoletti Margherita, Labate Marianna Eleonora, Porcari Aldostefano, Bordignon Luca, Merlo Marco, Sinagra Gianfranco, Tini Giacomo, Musumeci Beatrice, Barbato Emanuele, Autore Camillo, Biagini Elena, Longhi Simone, Sena Giuseppe, Ponziani Alberto, Saturi Giulia, Fico Vera, Argirò Alessia, Mazzoni Carlotta, Fumagalli Carlo, Olivotto Iacopo, Perfetto Federico, Cappelli Francesco

Abstract excerpt

BACKGROUND: The tenet of cardiac amyloidosis (CA) as a paradigm of heart failure with restrictive ventricular physiology and preserved systolic function has come under scrutiny. We aimed to evaluate the prevalence and clinical significance of left ventricular (LV) systolic dysfunction versus restriction in a large real-world cohort with CA, assessed at the time of diagnosis. METHODS: We retrospectively analyzed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid Neuropathies, Familial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Failure

Share to Heart Transplantation

Share to Prealbumin

Share to Stroke Volume

Share to Systole

Share to Ventricular Dysfunction, Left

Share to Ventricular Function, Left

Source

Open in PubMed Open full text

Identifiers

PMID: 41732853
DOI: 10.1161/CIRCHEARTFAILURE.125.012337
PMCID: PMC12986034

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prevalence and Prognostic Significance of Restriction Versus Systolic Dysfunction in Patients With Transthyretin and Light Chain Cardiac Amyloidosis.PMID 41732853Read ↗

Diversity of heart failure phenotypes in transthyretin amyloid cardiomyopathy. More than just heart failure with preserved ejection fraction.Semantic proximity Read ↗

Transthyretin cardiac amyloid: Broad heart failure phenotypic spectrum and implications for diagnosis.Semantic proximity Read ↗

Elevated filling pressures but rare restrictive physiology in transthyretin amyloid cardiomyopathy: genotype-specific patterns and the role of left atrial strain.Semantic proximity Read ↗

Echocardiographic phenotype and prognosis in transthyretin cardiac amyloidosis.Semantic proximity Read ↗

Relationship between aetiology and left ventricular systolic dysfunction in hypertrophic cardiomyopathy.Semantic proximity Read ↗

Echocardiographic and biohumoral characteristics in patients with AL and TTR amyloidosis at diagnosis.Semantic proximity Read ↗

Echocardiographic phenotype in severe aortic stenosis with and without transthyretin cardiac amyloidosis: the AMY-TAVI study.Semantic proximity Read ↗

Wild-type transthyretin amyloidosis as a cause of heart failure with preserved ejection fraction.Semantic proximity Read ↗

Sex Differences in the Phenotype of Transthyretin Cardiac Amyloidosis Due to Val122Ile Mutation: Insights from Noninvasive Pressure-Volume Analysis.Semantic proximity Read ↗

Phenotype and prognostic factors in geriatric and non-geriatric patients with transthyretin cardiomyopathy.Semantic proximity Read ↗

Multi-Imaging Characterization of Cardiac Phenotype in Different Types of Amyloidosis.Semantic proximity Read ↗

Echocardiographic phenotype for refined risk stratification and treatment selection in light chain amyloidosis with heart failure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.