Article
Analysis of gene-dosage effects on the expression of CD18 by trisomy 21 lymphoblastoid cell-lines using a statistical model to fit flow cytometry profiles.
Human genetics - 1 Dec 1990
Bardsley W G, McMurray B P, Robson A, D'Souza S, Taylor G M
Abstract excerpt
It is not clear whether Down syndrome, the phenotypic expression of constitutional trisomy for chromosome 21 (T21), is the result of generalised disruption of homeostasis resulting from genetic imbalance, or the over-expression of specific genes on chromosome 21. In order to understand the effect of gene dosage more clearly, we have analysed the predicted and actual levels of expression of the leucocyte integrin...
Topics
- CD18 Antigens
- Cell Line
- Down Syndrome
- Flow Cytometry
- Gene Expression
- Humans
- Models, Statistical
- Phenotype
- Receptors, Leukocyte-Adhesion