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Article

Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jan 2010

Donohoe Gary, Frodl Thomas, Morris Derek, Spoletini Ilaria, Cannon Dara M, Cherubini Andrea, Caltagirone Carlo, Bossù Paola, McDonald Colm, Gill Michael, Corvin Aiden P, Spalletta Gianfranco

Abstract excerpt

A three-marker C-A-T dysbindin haplotype identified by Williams et al (PMID: 15066891) is associated with increased risk for schizophrenia, decreased mRNA expression, poorer cognitive performance, and early sensory processing deficits. We investigated whether this same dysbindin risk haplotype was also associated with structural variation in the gray matter volume (GMV). Using voxel-based morphometry,...

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Identifiers

PMID: 19794403
DOI: 10.1038/npp.2009.140
PMCID: PMC3055383

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