Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PPFIA1 and CCND1 are frequently coamplified in breast cancer.

Genes, chromosomes & cancer - 1 Jan 2010

Dancau Ana-Maria, Wuth Laura, Waschow Marcel, Holst Frederik, Krohn Antje, Choschzick Matthias, Terracciano Luigi, Politis Sotirios, Kurtz Stefan, Lebeau Annette, Friedrichs Kay, Wencke Katharina, Monni Outi, Simon Ronald

Abstract excerpt

Recently, amplification of PPFIA1, encoding a member of the liprin family located about 600 kb telomeric to CCND1 on chromosome band 11q13, was described in squamous cell carcinoma of head and neck. Because 11q13 amplification is frequent in breast cancer, and PPFIA1 has been suggested to contribute to mammary gland development, we hypothesized that PPFIA1 might also be involved in the 11q13 amplicon in breast...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 11

Share to Cyclin D1

Share to Gene Amplification

Share to Gene Dosage

Share to Incidence

Share to Tissue Array Analysis

Source

Identifiers

PMID: 19787783
DOI: 10.1002/gcc.20713

Genes

PPFIA1
CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PPFIA1 and CCND1 are frequently coamplified in breast cancer.PMID 19787783Read ↗

Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis.Semantic proximity Read ↗

EMS1 amplification can occur independently of CCND1 or INT-2 amplification at 11q13 and may identify different phenotypes in primary breast cancer.Semantic proximity Read ↗

Prognostic Relevance of Gene Amplifications and Coamplifications in Breast CancerSemantic proximity Read ↗

High-resolution genomic analysis of the 11q13 amplicon in breast cancers identifies synergy with 8p12 amplification, involving the mTOR targets S6K2 and 4EBP1.Semantic proximity Read ↗

PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization studySemantic proximity Read ↗

Gene products of chromosome 11q and their association with CCND1gene amplification and tamoxifen resistance in premenopausal breast cancerSemantic proximity Read ↗

Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancersSemantic proximity Read ↗

CCND1 and ZNF217 gene amplification is equally frequent in BRCA1 and BRCA2 associated and non-BRCA breast cancer.Semantic proximity Read ↗

Molecular profiling of invasive breast cancer by multiplex ligation-dependent probe amplification-based copy number analysis of tumor suppressor and oncogenes.Semantic proximity Read ↗

Characterization of candidate gene copy number alterations in the 11q13 region along with BRAF and NRAS mutations in human melanoma.Semantic proximity Read ↗

Co-amplification of CCND1 and EMSY is associated with an adverse outcome in ER-positive tamoxifen-treated breast cancers.Semantic proximity Read ↗

Coamplification of DDX1 Correlates With an Improved Survival Probability in Children With MYCN-Amplified Human NeuroblastomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.