Independent genetic determinants of pancreatic and pulmonary status in cystic fibrosis.

doi:10.1016/0140-6736(90)92566-z

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Article

Independent genetic determinants of pancreatic and pulmonary status in cystic fibrosis.

Lancet (London, England) - 3 Nov 1990

Santis G, Osborne L, Knight R A, Hodson M E

Abstract excerpt

The concordance of pancreatic and pulmonary status among siblings with cystic fibrosis, the cystic fibrosis genotype, and non-genetic factors were analysed in adult patients with cystic fibrosis. Genetic factors were more important than non-genetic factors in affecting the severity of pancreatic and lung disease. The genetic factors were independent of each other and did not invariably cosegregate with specific...

Topics

Adult
Alleles
Blood Proteins
Calgranulin A
Chromosome Mapping
Cystic Fibrosis
DNA
Exocrine Pancreatic Insufficiency
Female
Forced Expiratory Volume
Homozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lung Diseases

Male

Middle Aged

Mutation

Phenotype

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 1977977
DOI: 10.1016/0140-6736(90)92566-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1977977-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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