Genetic analysis of the enhancer of zeste locus and its role in gene regulation in Drosophila melanogaster.

doi:10.1093/genetics/126.1.185

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Article

Genetic analysis of the enhancer of zeste locus and its role in gene regulation in Drosophila melanogaster.

Genetics - 1 Sept 1990

Jones R S, Gelbart W M

Abstract excerpt

The Enhancer of zeste [E(z)] locus of Drosophila melanogaster is implicated in multiple examples of gene regulation during development. First identified as dominant gain-of-function modifiers of the zeste1-white (z-w) interaction, mutant E(z) alleles also produce homeotic transformations. Reduction of E(z)+ activity leads to both suppression of the z-w interaction and ectopic expression of segment identity genes...

Topics

Alleles
Animals
Chromosome Mapping
Crosses, Genetic
Drosophila melanogaster
Enhancer Elements, Genetic
Female
Gene Expression Regulation
Genes, Homeobox
Genes, Lethal
Genes, Recessive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mutation

Phenotype

Suppression, Genetic

Temperature

Transformation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1977656
DOI: 10.1093/genetics/126.1.185
PMCID: PMC1204123

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1977656-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Genetic analysis of the enhancer of zeste locus and its role in gene regulation in Drosophila melanogaster.PMID 1977656Read ↗

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