Article
TNF-alpha gene polymorphisms in Iranian Azeri Turkish patients with Behcet's Disease.
Rheumatology international - 1 Dec 2009
Bonyadi Mortaza, Jahanafrooz Zohreh, Esmaeili Mohsen, Kolahi Susan, Khabazi Alireza, Ebrahimi Ali Asghar, Hajialilo Mehrzad, Dastgiri Saeed
Abstract excerpt
Genetic factors that predispose individuals to Behcet's disease (BD) are considered to play an important role in the development of the disease. The serum level of tumor necrosis factor (TNF) is elevated in patients with BD, and a dramatic response to anti-TNF-alpha antibody treatment further supports the role of TNF in BD. We investigated the distribution of TNF-alpha promoter -1031T/C and -308G/A polymorphisms...
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