Article
The feasibility of using high resolution genome sequencing of influenza A viruses to detect mixed infections and quasispecies.
PloS one - 22 Sept 2009
Ramakrishnan Muthannan A, Tu Zheng Jin, Singh Sushmita, Chockalingam Ashok K, Gramer Marie R, Wang Ping, Goyal Sagar M, Yang My, Halvorson David A, Sreevatsan Srinand
Abstract excerpt
BACKGROUND: The rapidly expanding availability of de novo sequencing technologies can greatly facilitate efforts to monitor the relatively high mutation rates of influenza A viruses and the detection of quasispecies. Both the mutation rates and the lineages of influenza A viruses are likely to play an important role in the natural history of these viruses and the emergence of phenotypically and antigenically...
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