Genome-wide association studies: hypothesis-"free" or "engaged"?

Abstract excerpt

The advent of the first wave of genome-wide association studies (GWAS) provided a new conceptual framework in the search for variants underlying common disorders: a massive scan of the genome, free from underlying assumptions for biological or positional candidate loci, genes, and variants. Thus, GWAS have been labeled as a "hypothesis-free" or "agnostic" approach, overcoming the obstacles imposed by the...

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