Article
Lack of association between two restriction fragment length polymorphisms in the genes for the light and heavy neurofilament proteins and Alzheimer's disease.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques - 1 Aug 1990
Lacoste-Royal G, Mathieu M, Nalbantoglu J, Julien J P, Gauthier S, Gauvreau D
Abstract excerpt
The etiology of Alzheimer disease (AD) remains unknown. The hypothesis of genetic factors playing a role in the causation of the disease, at least in its familial form, has been borne out by results showing linkage in several early-onset AD families to a locus on the proximal part of the long arm...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Blotting, Southern
- DNA
- Female
- Genetic Markers
- Genotype
- Humans
- Intermediate Filament Proteins
- Male
- Middle Aged
- Neurofilament Proteins
- Polymorphism, Restriction Fragment Length
- Restriction Mapping