Article
Recommendations to improve identification of hereditary and familial colorectal cancer in Europe.
Familial cancer - 1 Jun 2010
Vasen H F A, Möslein G, Alonso A, Aretz S, Bernstein I, Bertario L, Blanco I, Bulow S, Burn J, Capella G, Colas C, Engel C, Frayling I, Rahner N, Hes F J, Hodgson S, Mecklin J-P, Møller P, Myrhøj T, Nagengast F M, Parc Y, Ponz de Leon M, Renkonen-Sinisalo L, Sampson J R, Stormorken A, Tejpar S, Thomas H J W, Wijnen J, Lubinski J, Järvinen H, Claes E, Heinimann K, Karagiannis J A, Lindblom A, Dove-Edwin I, Müller H
Abstract excerpt
Familial colorectal cancer (CRC) accounts for 10-15% of all CRCs. In about 5% of all cases, CRC is associated with a highly penetrant dominant inherited syndrome. The most common inherited form of non-polyposis CRC is the Lynch syndrome which is responsible for about 2-4% of all cases. Surveillance of individuals at high risk for CRC prevents the development of advanced CRC. About 1 million individuals in Western...
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