Article
Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains.
The Journal of biological chemistry - 20 Nov 2009
Noguchi Akihiko, Matsumura Satoko, Dezawa Mari, Tada Mari, Yanazawa Masako, Ito Akane, Akioka Manami, Kikuchi Satoru, Sato Michio, Ideno Shouji, Noda Munehiro, Fukunari Atsushi, Muramatsu Shin-ichi, Itokazu Yutaka, Sato Kazuki, Takahashi Hitoshi, Teplow David B, Nabeshima Yo-ichi, Kakita Akiyoshi, Imahori Kazutomo, Hoshi Minako
Abstract excerpt
Amyloid beta-protein (Abeta) assemblies are thought to play primary roles in Alzheimer disease (AD). They are considered to acquire surface tertiary structures, not present in physiologic monomers, that are responsible for exerting toxicity, probably through abnormal interactions with their target(s). Therefore, Abeta assemblies having distinct surface tertiary structures should cause neurotoxicity through...
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