Article
Antibodies to neurofilaments.
Annals of the New York Academy of Sciences - 1 Sept 2009
Talja Ija, Reimand Tiia, Uibo Oivi, Reimand Koit, Aun Silver, Talvik Tiina, Janmey Paul A, Uibo Raivo
Abstract excerpt
Immune responses to neuronal proteins are a frequent occurrence in neurodegenerative diseases. This study determines the occurrence of autoantibodies to the three neurofilament subunits in phosphorylated and dephosphorylated forms and relates these measures to age, human leukocyte antigen (HLA), and severity of disease in Down syndrome (DS). IgG-type antibodies to three neurofilament (NF) subunits, NF-L, NF-M,...
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