Article
Heritable factors play a major role in determining host responses to Wuchereria bancrofti infection in an isolated South Pacific island population.
The Journal of infectious diseases - 15 Oct 2009
Cuenco Karen T, Ottesen Eric A, Williams Steven A, Nutman Thomas B, Steel Cathy
Abstract excerpt
BACKGROUND: It is increasingly recognized that host genetic factors may play an important role in determining the outcome of filarial infections. To test this hypothesis in bancroftian lymphatic filariasis, pedigree data were collected twice during an 18-year period from an isolated Polynesian population living on a Pacific island where lymphatic filariasis is endemic. METHODS: Using variance-component analysis,...
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