Article
Impact of genetic polymorphisms in cytomegalovirus glycoprotein B on outcomes in solid-organ transplant recipients with cytomegalovirus disease.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Oct 2009
Manuel Oriol, Asberg Anders, Pang Xiaoli, Rollag Halvor, Emery Vincent C, Preiksaitis Jutta K, Kumar Deepali, Pescovitz Mark D, Bignamini Angelo A, Hartmann Anders, Jardine Alan G, Humar Atul
Abstract excerpt
BACKGROUND: It is unknown whether specific viral polymorphisms affect in vivo therapeutic response in patients with cytomegalovirus (CMV) disease. Polymorphisms in the CMV glycoprotein B (gB) gene allow discrimination of 4 distinct genotypes (gB1-gB4). We assessed the influence of gB genotypes on the clinical and virologic outcome of CMV disease. METHODS: Solid-organ transplant recipients enrolled in a...
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