Article
Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer.
Cancer letters - 1 Mar 2010
Frye Michaela, Dragoni Ilaria, Chin Suet-Feung, Spiteri Immaculada, Kurowski Agata, Provenzano Elena, Green Andrew, Ellis Ian O, Grimmer Donna, Teschendorff Andrew, Zouboulis Christos C, Caldas Carlos, Watt Fiona M
Abstract excerpt
We have examined expression of the Myc target gene Misu (NSUN2) in breast cancer. There was extensive copy number gain, and increased mRNA and protein levels, of Misu in approximately one third of breast cancer cell lines and primary tumours examined, irrespective of tumour subtype. Genes on 5p15.31-33, where Misu is located, showed evolutionary synteny. siRNA-mediated knockdown of Misu reduced cell number in...
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