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Homoharringtonine, omacetaxine mepesuccinate, and chronic myeloid leukemia circa 2009

8 Sept 2009

Abstract excerpt

Homoharringtonine (HHT) is a natural alkaloid that is obtained from various Cephalotaxus species. The mechanism of action by which HHT exerts its antitumor activity is through inhibition of protein synthesis and promotion of apoptosis. In the 1990s, HHT proved to be significantly active as salvage therapy for patients with chronic myeloid leukemia (CML) after failure on interferon-alpha therapy. However, the...

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PMID: 19739234
DOI: 10.1002/cncr.24601

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