A developmental systems perspective on epistasis: computational exploration of mutational interactions in model developmental regulatory networks.

Abstract excerpt

The way in which the information contained in genotypes is translated into complex phenotypic traits (i.e. embryonic expression patterns) depends on its decoding by a multilayered hierarchy of biomolecular systems (regulatory networks). Each layer of this hierarchy displays its own regulatory schemes (i.e. operational rules such as +/- feedback) and associated control parameters, resulting in characteristic...

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