Article
Induction of dominant lethal mutations by Ascaris trypsin inhibitor in male mice.
Reproductive toxicology (Elmsford, N.Y.) - 1 Jan 2010
Blaszkowska Joanna
Abstract excerpt
Trypsin inhibitor (ATI) isolated from Ascaris suum, a gastrointestinal nematode parasite, was tested for the induction of dominant lethal mutations in male mice. Dominant lethal effects of ATI for the main stages of germ cell development were analyzed by mating at specific time points after dosing. Three groups of adult BALB/c males received 50, 100 or 250mg/kg body weight (bw) single intraperitoneal (ip)...
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