Article
Immunophenotypic and cell cycle analysis of lymph node cells from dimethylbenzanthracene-treated mice.
Virchows Archiv. B, Cell pathology including molecular pathology - 1 Jan 1990
Halliday G M, Cavanagh L L, Muller H K
Abstract excerpt
The chemical carcinogen 7, 12-dimethylbenz-(a)anthracene (DMBA) depletes Langerhans cells from murine epidermis. Application of contact sensitizers to DMBA-treated skin induces specific immunological tolerance due to a DMBA-resistant epidermal antigen presenting cell (APC) migrating to local lymph nodes where it presents antigen in a way which activates suppressor cells. As alterations in local lymph node...
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