Article
Linkage between a PvuII restriction fragment length polymorphism and G6PD A-202A/376G: evidence for a single origin of the common G6PD A- mutation.
Human genetics - 1 Jun 1990
Beutler E, Kuhl W
Abstract excerpt
DNA samples from 29 males with the G6PD A- phenotype and 14 males with a G6PD B phenotype were studied for the presence of each of four polymorphic restriction sites in the glucose-6-phosphate dehydrogenase locus. All G6PD A- subjects with the G6PD A-202A/376G genotype, regardless of population origin, shared identical haplotypes. In view of the fact that at least one of the restriction sites, the PvuII site in...
Topics
- Base Sequence
- DNA Mutational Analysis
- Deoxyribonucleases, Type II Site-Specific
- Ethnicity
- Genetic Linkage
- Glucosephosphate Dehydrogenase
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction