Article
Leishmania major: nature of immunity induced by immunization with a mutagenized avirulent clone of the parasite in mice.
Experimental parasitology - 1 Jul 1990
McGurn M, Boon T, Louis J A, Titus R G
Abstract excerpt
A chemically mutagenized avirulent form of Leishmania major was used to immunize BALB/c and C57B1/6 mice against challenge with virulent L. major. Immunity was elicited when the avirulent parasite was injected intravenously or intraperitoneally, but not subcutaneously. In fact, the latter route o...
Topics
- Animals
- CD4-Positive T-Lymphocytes
- Female
- Hypersensitivity, Delayed
- Immunization
- Immunization, Passive
- Leishmania tropica
- Leishmaniasis
- Lymph Nodes
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mutation
- Spleen
- T-Lymphocytes, Regulatory
- Virulence