Article
Dramatic increase in signal by integration of polymerase chain reaction and hybridization on surface of DNA microarray.
Analytical biochemistry - 1 Jan 2010
Kim Kyung-Tae, Na Chan Hyun, Yun Yeo Min, Hwang Tae Sook, Kim Soo Nyung, Chae Chi-Bom
Abstract excerpt
The cumbersome process required for diagnosis by DNA microarray can be simplified by simple extraction of nucleic acid from cells and by integration of liquid-phase polymerase chain reaction (PCR) and hybridization on the surface of a microarray slide. An unexpected benefit was the large (five- to sixfold) increase in detection signal that also is translated into an increase in sensitivity and the confidence...
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