Article
[Allelic polymorphism of the IL-2and IL-4 genes in herpesvirus infection].
Klinicheskaia laboratornaia diagnostika - 1 Jul 2009
Naslednikova I O, Novitskiĭ V V, Urazova O I, Gorbunova E B, Sukhalentseva N A, Chernov A S, Reshetnikov V I, Shperling N V, Pronina N A, Chaĭkovskiĭ A V, Chernova E N, Bezmenova M A, Sharopina A V, Voronkova O V
Abstract excerpt
Herpesvirus infection is accompanied by imbalance of peripheral mononuclear production of cytokines, by polarizing an immune response by the Th2 pathway. The homozygous TT genotype of T330G polymorphism in the IL-2 gene is an immunogenetic factor that has a protective activity against susceptibility to herpesvirus infection. The risk of progression, the recurrent course of the infection and its poor outcome is...
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